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Spinoza award for Cisca Wijmenga

At NWO’s Bessensap event on 12th June, it was announced that Cisca Wijmenga is one of four NWO Spinoza prize winners for 2015. The NWO Spinoza prize in brief The NWO Spinoza prize is the highest award in the Netherlands science arena and can be seen as the ‘Dutch Nobel Prize’. Each year, NWO awards Spinoza prizes to three or four researchers working in the Netherlands who, according to international standards, belong at the very top of their scientific field. NWO Spinoza laureates perform ground-breaking research that has a major impact and they are a source of inspiration to younger researchers. The prize winners

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Intern Dirk de Weerd wins poster prize

Automated NIPT diagnostics pipeline. The development of an automated Non Invasive Prenatal Test analysis pipeline using MOLGENIS compute framework by H.A. de Weerd, F. van Dijk, E.N. de Boer, M. Dijkstra, B. Sikkema-Raddatz, G.J. te Meerman, M.A. Swertz and L.F. Johansson Department of Genetics, and Genomics Coordination Center, Department of Genetics, University Medical Center Groningen, the Netherlands Dirk de Weerd’s poster on NIPT has won a prize in the Hanze University’s Institute of Life Science and Technology poster competition, which had some 100 submissions from students taking courses at HBO/undergraduate/Bachelor of Applied Science level, for example, in bioinformatics, chemistry, and

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UMCG Research prize to Lude Franke

The UMCG Research prize was awarded to Lude Franke at the New Year Reception, held on January 6th. This is in recognition of his achievements over the past few years: gaining an ERC starting grant, an NWO-VIDI, and publishing many papers in top journals. For more information see his personal page

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Dutch genome deciphered

The family tree of the Dutch people has been deciphered by researchers at 5 Dutch universities under the leadership of Prof. Cisca Wijmenga of the UMCG in Groningen. The early history of the Dutch can be re-written and diseases can be better predicted. The research is described in a Nature Genetics article published yesterday. `Paul de Bakker, Cisca Wijmenga and colleagues report on The Genome of the Netherlands Project, including whole-genome sequencing of 769 individuals of Dutch ancestry from 250 parent-offspring families and construction of a phased haplotype map. Their intermediate-coverage population sequencing data set provides a complementary resource to

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GUT paper on coeliac disease in F1000Prime

A recent paper by the Wijmenga group has been selected for F1000Prime. It was recommended as being of special significance in its field by Faculty Member Piero Portincasa. “Improving coeliac disease risk prediction by testing non-HLA variants additional to HLA variants” by Jihane Romanos, …Vinod Kumar, Gosia Trynka, Lude Franke, Agata Szperl, Javier Gutierrez-Achury, Cleo C van Diemen, Roan Kanninga, Soesma A Jankipersadsing, … Cisca Wijmenga, and the PreventCD Group. Published in Gut, 2014 Mar;63(3):415-22. Open access full text. Epub 2013 May 23. “In this paper, the authors highlight the importance of a more comprehensive genetic test for the diagnosis of

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Trans eQTL paper by Westra et al. in Nature Genetics

Systematic identification of trans eQTLs as putative drivers of known disease associations, Westra et al. Harm-Jan Westra, … Alexandra Zhernakova, Daria V Zhernakova, … Juha Karjalainen, Sebo Withoff, … Yang Li, Ritsert C Jansen, … Lude Franke, of Dept of Genetics, UMCG, Groningen Published in Nature Genetics online: 08 September 2013 Lude Franke and colleagues report the results of a large expression QTL study performed on peripheral blood samples from 5,311 individuals. They identify trans-eQTL effects for 103 independent loci that were previously associated with complex traits at genome-wide significance, suggesting that this approach can provide insights into the downstream effects of many trait-associated variants.

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VENI grant for Yang Li

Dr. Yang Li, a postdoc working in the Wijmenga group, has been awarded an NWO VENI grant (€250,000) to perform systems genetics analyses on metabolic fluxes using yeast as a model system. Genetic analyses on multiple molecular levels can provide insight into how a genotype relates to a phenotype. She will use this approach to look for heritable causes of metabolite flow rate (flux) through metabolic pathways. See her homepage

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Genome of the Netherlands, Eur J Hum Genet, 2013

The Dept of Genetics (UMCG, Groningen, NL) is the coordinator, and the Genomics Coordination Center (GCC) is the data stewardship center, for all GoNL data (500 TB) generated by the Dutch BBMRI-NL national consortium. We coordinated the analyses; managed the project; hosted raw, intermediate and result data; and developed and now run all the necessary computing pipelines (together with CIT, BigGrid, eBioGrid, NBIC). The resulting state-of-the-art NGS and imputation pipeline can be easily ported to new computer clusters and grids, and is available as a service from the GCC. See: Boomsma DI, Wijmenga C, Slagboom EP, Swertz MA, et al

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