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Dutch genome deciphered

The family tree of the Dutch people has been deciphered by researchers at 5 Dutch universities under the leadership of Prof. Cisca Wijmenga of the UMCG in Groningen. The early history of the Dutch can be re-written and diseases can be better predicted. The research is described in a Nature Genetics article published yesterday. `Paul de Bakker, Cisca Wijmenga and colleagues report on The Genome of the Netherlands Project, including whole-genome sequencing of 769 individuals of Dutch ancestry from 250 parent-offspring families and construction of a phased haplotype map. Their intermediate-coverage population sequencing data set provides a complementary resource to

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2 VIDI grants awarded

May 2014: NWO (Netherlands Organisation for Scientific Research) has awarded VIDI grants to Jingyuan Fu for her project on “Understanding the causal relationships between the host genome, microbiota and lipids” and to Lude Franke for his project on “A novel approach to understanding how DNA variants cause disease”. (1) Understanding the causal relationships between the host genome, microbiota and lipids - Dr. Jingyuan Fu Lipid composition varies widely between human individuals and is associated with many diseases. Numerous studies have shown that the lipid composition can be affected by an individual’s genetic make-up and intestinal microbial composition. Over millions of years, microbes and humans have formed a truly symbiotic relationship.

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GUT paper on coeliac disease in F1000Prime

A recent paper by the Wijmenga group has been selected for F1000Prime. It was recommended as being of special significance in its field by Faculty Member Piero Portincasa. “Improving coeliac disease risk prediction by testing non-HLA variants additional to HLA variants” by Jihane Romanos, …Vinod Kumar, Gosia Trynka, Lude Franke, Agata Szperl, Javier Gutierrez-Achury, Cleo C van Diemen, Roan Kanninga, Soesma A Jankipersadsing, … Cisca Wijmenga, and the PreventCD Group. Published in Gut, 2014 Mar;63(3):415-22. Open access full text. Epub 2013 May 23. “In this paper, the authors highlight the importance of a more comprehensive genetic test for the diagnosis of

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VENI grant for Yang Li

Dr. Yang Li, a postdoc working in the Wijmenga group, has been awarded an NWO VENI grant (€250,000) to perform systems genetics analyses on metabolic fluxes using yeast as a model system. Genetic analyses on multiple molecular levels can provide insight into how a genotype relates to a phenotype. She will use this approach to look for heritable causes of metabolite flow rate (flux) through metabolic pathways. See her homepage

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